Fibrin assembly in human plasma and fibrinogen/albumin mixtures.

@article{Torbet1986FibrinAI,
  title={Fibrin assembly in human plasma and fibrinogen/albumin mixtures.},
  author={Jim Torbet},
  journal={Biochemistry},
  year={1986},
  volume={25 18},
  pages={5309-14}
}
Magnetic birefringence is used to monitor the kinetics of thrombin-catalyzed fibrin polymerization in model systems of increasing complexity (i.e., fibrinogen solutions, fibrinogen/albumin mixtures, and plasma anticoagulated with citrate) and in plasma containing free calcium which is the physiological condition. The introduction of albumin into fibrinogen solutions shortens the lag period and enhances fiber thickness. The polymerization progress curves are sigmoidal at zero or low albumin… CONTINUE READING