Fibrin Sealant: Past, Present, and Future: A Brief Review

  title={Fibrin Sealant: Past, Present, and Future: A Brief Review},
  author={William D. Spotnitz},
  journal={World Journal of Surgery},
Fibrin sealant is a two-component topical hemostat, sealant, and tissue adhesive consisting of fibrinogen and thrombin that has been used in the United States as a blood bank- or laboratory-derived product since the 1980s and has been commercially available since 1998. Initially, surgeons employed hospital-based materials because of the lack of availability of a commercially produced agent. At present, there are five U.S. Food and Drug Administration (FDA)-approved forms including products… CONTINUE READING