Fibrin II induces endothelial cell capillary tube formation

  title={Fibrin II induces endothelial cell capillary tube formation},
  author={D G Chalupowicz and Z A Chowdhury and Tami L Bach and Carl Barsigian and Jean Martinez},
  journal={The Journal of Cell Biology},
  pages={207 - 215}
We studied the formation of capillary tubes by endothelial cells which were sandwiched between two fibrin gels under serum-free conditions. After formation of the overlying fibrin gel, the endothelial cell monolayer rearranged into an extensive net of capillary tubes. Tube formation was apparent at 5 h and was fully developed by 24 h. The capillary tubes were vacuolated, and both intracellular and intercellular lumina were present. Maximal tube formation was observed with fibrin II (which lacks… CONTINUE READING


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