Fibrin Clots Are Equilibrium Polymers That Can Be Remodeled Without Proteolytic Digestion

  title={Fibrin Clots Are Equilibrium Polymers That Can Be Remodeled Without Proteolytic Digestion},
  author={Irina N. Chernysh and Chandrasekaran Nagaswami and Prashant K Purohit and John W. Weisel},
  booktitle={Scientific reports},
Fibrin polymerization is a necessary part of hemostasis but clots can obstruct blood vessels and cause heart attacks and strokes. The polymerization reactions are specific and controlled, involving strong knob-into-hole interactions to convert soluble fibrinogen into insoluble fibrin. It has long been assumed that clots and thrombi are stable structures until proteolytic digestion. On the contrary, using the technique of fluorescence recovery after photobleaching, we demonstrate here that there… CONTINUE READING
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