Fibrils from synthetic amyloid-related peptides enhance development of experimental AA-amyloidosis in mice.

@article{Ganowiak1994FibrilsFS,
  title={Fibrils from synthetic amyloid-related peptides enhance development of experimental AA-amyloidosis in mice.},
  author={K Ganowiak and Per Hultman and Ulla Engstroem and Asa Gustavsson and Per Westermark},
  journal={Biochemical and biophysical research communications},
  year={1994},
  volume={199 1},
  pages={306-12}
}
Amyloid enhancing factor is an incompletely characterized activity of extracts from many amyloid-containing tissues and which greatly shortens the preamyloidotic phase during experimental induction of AA-amyloidosis. In this communication we show that amyloid-like fibrils made in vitro from synthetic peptides, corresponding to segments of amyloid fibril proteins, have amyloid enhancing factor-like activity. Thus, there is a possibility that amyloid enhancing factor activity depends on small… CONTINUE READING

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