Fibrillins in adult human ovary and polycystic ovary syndrome: is fibrillin-3 affected in PCOS?

@article{Jordan2010FibrillinsIA,
  title={Fibrillins in adult human ovary and polycystic ovary syndrome: is fibrillin-3 affected in PCOS?},
  author={Carolyn D Jordan and Sandra D Bohling and Noe L. Charbonneau and Lynn Y. Sakai},
  journal={The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society},
  year={2010},
  volume={58 10},
  pages={903-15}
}
Polycystic ovary syndrome (PCOS) is a common endocrinopathy in women of reproductive age. Although genetic linkage analyses have demonstrated a susceptibility locus for PCOS mapping to the fibrillin-3 gene, the presence of fibrillin proteins in normal and polycystic ovaries has not been characterized. This study compared and contrasted fibrillin-1, -2, and -3 localization in normal and polycystic ovaries. Immunohistochemical stainings of ovaries from 21 controls and 9 patients with PCOS were… CONTINUE READING

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