Fibrillins 1 and 2 perform partially overlapping functions during aortic development.

@article{Carta2006Fibrillins1A,
  title={Fibrillins 1 and 2 perform partially overlapping functions during aortic development.},
  author={Luca Carta and Lygia Pereira and Emilio Arteaga-Solis and Sui Y Lee-Arteaga and Brett Lenart and Barry Starcher and Christian A. Merkel and Marina Sukoyan and Alexandre Kerkis and Noriko Hazeki and Douglas R Keene and Lynn Y Sakai and F. J. Estrada Ram{\'i}rez},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 12},
  pages={
          8016-23
        }
}
Fibrillin-rich microfibrils are extracellular assemblies that impart structural properties to the connective tissue. To elucidate the contribution of fibrillin-rich microfibrils to organogenesis, we have examined the vascular phenotype of a newly created strain of mice that completely lacks fibrillin-1 and the consequences of combined deficiency of fibrillins 1 and 2 on tissue formation. The results demonstrated that fibrillins 1 and 2 perform partially overlapping functions during aortic… CONTINUE READING
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