Fibrillin-rich microfibrils are reduced in photoaged skin. Distribution at the dermal-epidermal junction.

@article{Watson1999FibrillinrichMA,
  title={Fibrillin-rich microfibrils are reduced in photoaged skin. Distribution at the dermal-epidermal junction.},
  author={Rachel E. B. Watson and Christopher Griffiths and Nicoletta Craven and C. Adrian Shuttleworth and Cay M Kielty},
  journal={The Journal of investigative dermatology},
  year={1999},
  volume={112 5},
  pages={
          782-7
        }
}
Chronic sun exposure results in photoaged skin with deep coarse wrinkles and loss of elasticity. We have examined the distribution and abundance of fibrillin-rich microfibrils, key structural components of the elastic fiber network, in photoaged and photoprotected skin. Punch biopsies taken from photoaged forearm and from photoprotected hip and upper inner arm of 16 subjects with a clinical range of photoaging were examined for fibrillin-1 and fibrillin-2 expression and microfibril distribution… CONTINUE READING

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