Fibrillin-1 genotype is associated with aortic stiffness and disease severity in patients with coronary artery disease.

@article{Medley2002Fibrillin1GI,
  title={Fibrillin-1 genotype is associated with aortic stiffness and disease severity in patients with coronary artery disease.},
  author={Tanya L Medley and Timothy J. Cole and Christoph D. Gatzka and William Y. S. Wang and Anthony M Dart and Bronwyn A. Kingwell},
  journal={Circulation},
  year={2002},
  volume={105 7},
  pages={810-5}
}
BACKGROUND Elevated pulse pressure is associated strongly with adverse cardiovascular outcome; however, the genetic basis of this condition is unknown. This study examined whether genotypic variation in the extracellular matrix protein fibrillin-1, the Marfan gene, was associated with aortic stiffening and therefore could contribute to cardiovascular risk associated with pulse pressure elevation in coronary disease. METHODS AND RESULTS Patients (n=145; 113 men), 62+/-9 years of age (mean+/-SD… CONTINUE READING
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