Fibrillar L-amyloid Evokes Oxidative Damage in a Transgenic Mouse Model of Alzheimer ' S Disease

@inproceedings{Matsuoka2001FibrillarLE,
  title={Fibrillar L-amyloid Evokes Oxidative Damage in a Transgenic Mouse Model of Alzheimer ' S Disease},
  author={Yasuji Matsuoka and M V Picciano and Juan L. François and Karen E Duff},
  year={2001}
}
L-Amyloid is one of the most signi¢cant features of Alzheimer's disease, and has been considered to play a pivotal role in neurodegeneration through an unknown mechanism. However, it has been noted that L-amyloid accumulation is associated with markers of oxidative stress including protein oxidation (Smith et al., 1997), lipid peroxidation (Mark et al., 1997; Sayre et al., 1997), advanced glycation end products (Smith et al., 1994), and oxidation of nucleic acids (Nunomura et al., 1999… CONTINUE READING
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