Fibers in the extracellular matrix enable long-range stress transmission between cells.

  title={Fibers in the extracellular matrix enable long-range stress transmission between cells.},
  author={Xiaoyue Ma and Maureen E Schickel and M. D. Stevenson and Alisha L Sarang-Sieminski and Keith J. Gooch and Samir N Ghadiali and Richard T. Hart},
  journal={Biophysical journal},
  volume={104 7},
Cells can sense, signal, and organize via mechanical forces. The ability of cells to mechanically sense and respond to the presence of other cells over relatively long distances (e.g., ∼100 μm, or ∼10 cell-diameters) across extracellular matrix (ECM) has been attributed to the strain-hardening behavior of the ECM. In this study, we explore an alternative hypothesis: the fibrous nature of the ECM makes long-range stress transmission possible and provides an important mechanism for long-range… CONTINUE READING
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