Fiber types in mammalian skeletal muscles.
@article{Schiaffino2011FiberTI,
title={Fiber types in mammalian skeletal muscles.},
author={Stefano Schiaffino and Carlo Reggiani},
journal={Physiological reviews},
year={2011},
volume={91 4},
pages={
1447-531
}
}Mammalian skeletal muscle comprises different fiber types, whose identity is first established during embryonic development by intrinsic myogenic control mechanisms and is later modulated by neural and hormonal factors. The relative proportion of the different fiber types varies strikingly between species, and in humans shows significant variability between individuals. Myosin heavy chain isoforms, whose complete inventory and expression pattern are now available, provide a useful marker for…
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References
SHOWING 1-10 OF 965 REFERENCES
Myosin isoforms, muscle fiber types, and transitions
- BiologyMicroscopy research and technique
- 2000
The fiber population of skeletal muscles encompasses a continuum of pure and hybrid fiber types, and under certain conditions, changes can be induced in MHC isoform expression heading in the direction of either fast‐to‐slow or slow‐ to‐fast.
Differential expression of muscle regulatory factor genes in normal and denervated adult rat hindlimb muscles
- BiologyDevelopmental dynamics : an official publication of the American Association of Anatomists
- 1993
Examination of the expression patterns of four basic/helix‐loop‐helix muscle regulatory factors (MRFs) in normal adult rat muscles suggest that myogenin, as well as the other three MRFs, may be involved in both the initial establishment aswell as maintenance of fiber‐type diversity in the developing organism.
Phenotype of adult mouse muscle myoblasts reflects their fiber type of origin.
- BiologyDifferentiation; research in biological diversity
- 1996
A population of satellite cells that form myotubes expressing type I (slow) myosin heavy chain is identified and found to be preferentially associated with individual slow muscle-fibers, confirming diversity among mammalian satellite cells and demonstrating that the phenotype ofatellite cells is indicative of the type of fiber from which they derive.
Human single masseter muscle fibers contain unique combinations of myosin and myosin binding protein C isoforms
- BiologyJournal of Muscle Research & Cell Motility
- 2004
A unique myofibrillar protein isoform expression was observed in the human masseter muscle fibers, suggesting significant differences in structural and functional properties between muscle fibers from humanmasseter and limb muscles.
Myosin expression and specialization among the earliest muscle fibers of the developing avian limb.
- BiologyDevelopmental biology
- 1986
Single-fiber myosin heavy-chain isoform composition of rodent laryngeal muscle: modulation by thyroid hormone.
- Medicine, BiologyArchives of otolaryngology--head & neck surgery
- 2000
The findings of this study support the concept that single-fiber MyHC polymorphism occurs commonly in mammalian laryngeal muscle.
Muscles of a different 'color'
- BiologyNeurology
- 1996
The characteristics of small motor unit size, precise dependence of muscle force upon motor neuron discharge rate, high contractile speed but low tension development, and contractile protein heterogeneity contribute toward the high precision and diversity that is required for eye movements.
Isoform switching in myofibrillar and excitation-contraction coupling proteins contributes to diminished contractile function in regenerating rat soleus muscle.
- BiologyJournal of applied physiology
- 2007
It is indicated that the expression of developmental proteins determines the incomplete functional recovery of regenerating soleus, particularly at the single-fiber level.
Microgenomic Analysis in Skeletal Muscle: Expression Signatures of Individual Fast and Slow Myofibers
- BiologyPloS one
- 2011
A first catalogue of genes expressed in mouse slow-oxidative and fast-glycolytic fibers through transcriptome analysis at the single fiber level (microgenomics) is produced, allowing a better understanding of the adaptive transcriptomic transitions occurring in myofibers under physiological and pathological conditions.



















