Fiber type conversion alters inactivation of voltage-dependent sodium currents in murine C2C12 skeletal muscle cells.

@article{Zebedin2004FiberTC,
  title={Fiber type conversion alters inactivation of voltage-dependent sodium currents in murine C2C12 skeletal muscle cells.},
  author={Eva Zebedin and Walter Sandtner and Stefan Galler and Julia Szendroedi and Herwig Just and Hannes Todt and Karlheinz Hilber},
  journal={American journal of physiology. Cell physiology},
  year={2004},
  volume={287 2},
  pages={
          C270-80
        }
}
Each skeletal muscle of the body contains a unique composition of "fast" and "slow" muscle fibers, each of which is specialized for certain challenges. This composition is not static, and the muscle fibers are capable of adapting their molecular composition by altered gene expression (i.e., fiber type conversion). Whereas changes in the expression of contractile proteins and metabolic enzymes in the course of fiber type conversion are well described, little is known about possible adaptations… CONTINUE READING

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