Fiber-mosaic adenovirus as a novel approach to design genetically modified adenoviral vectors.

@article{Pereboeva2004FibermosaicAA,
  title={Fiber-mosaic adenovirus as a novel approach to design genetically modified adenoviral vectors.},
  author={Larisa Pereboeva and Svetlana Komarova and Parameshwar J Mahasreshti and David T. Curiel},
  journal={Virus research},
  year={2004},
  volume={105 1},
  pages={
          35-46
        }
}
Genetic modification of the adenovirus (Ad) capsid is one of the successful strategies to achieve viral retargeting. However, it has been widely recognized that structural constraints imposed by viral proteins limit the number and nature of incorporated targeting ligands and often hamper viral propagation. To address this issue, we propose a genetic fiber-mosaic virus (having two distinct fibers in one viral particle) as a means to facilitate fiber modifications. Fiber-mosaic virus having… CONTINUE READING

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