Fiber atrophy and hypertrophy in skeletal muscles of late middle-aged Fischer 344 x Brown Norway F1-hybrid rats.

@article{Hepple2004FiberAA,
  title={Fiber atrophy and hypertrophy in skeletal muscles of late middle-aged Fischer 344 x Brown Norway F1-hybrid rats.},
  author={Russell T Hepple and Karen D Ross and Amanda B Rempfer},
  journal={The journals of gerontology. Series A, Biological sciences and medical sciences},
  year={2004},
  volume={59 2},
  pages={108-17}
}
We examined young adult and late middle-aged male rats to test the hypothesis that gastrocnemius (a locomotor muscle) demonstrates reduced fiber size with aging, whereas soleus (a postural muscle) demonstrates atrophy of some fibers and compensatory hypertrophy in other fibers. Although body mass was greater in late middle-aged animals, mass was reduced in gastrocnemius but not soleus muscle. In another group of animals, physical activity was reduced by 34% in late middle-aged animals. Whereas… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 47 references

Ageing and human muscle: observations from Sweden.

Canadian journal of applied physiology = Revue canadienne de physiologie appliquee • 1993
View 6 Excerpts
Highly Influenced

Muscle fiber type composition of the rat hindlimb.

The American journal of anatomy • 1984
View 5 Excerpts
Highly Influenced

Apoptosis in skeletal muscle with aging.

American journal of physiology. Regulatory, integrative and comparative physiology • 2002
View 1 Excerpt

Effects of aging on capillary number and luminal size in rat soleus and plantaris muscles.

The journals of gerontology. Series A, Biological sciences and medical sciences • 2002
View 1 Excerpt

Effects of long-term denervation on skeletal muscle in old rats

BM Carlson, Borisov, B Andrei
J Gerontol Biol Sci • 2002
View 1 Excerpt

Concepts and Theories of Aging

SN Austad
Masoro EJ, Austad SN, eds. Handbook of the Biology of Aging, • 2001
View 2 Excerpts

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