Fiber-Modified Adenovirus Vectors Decrease Liver Toxicity through Reduced IL-6 Production1

@article{Koizumi2007FiberModifiedAV,
  title={Fiber-Modified Adenovirus Vectors Decrease Liver Toxicity through Reduced IL-6 Production1},
  author={Naoya Koizumi and Tomoko Yamaguchi and Kenji Kawabata and Fuminori Sakurai and Tomomi Sasaki and Yoshiteru Watanabe and Takao Hayakawa and Hiroyuki Mizuguchi},
  journal={The Journal of Immunology},
  year={2007},
  volume={178},
  pages={1767 - 1773}
}
Adenovirus (Ad) vectors are one of the most commonly used viral vectors in gene therapy clinical trials. However, they elicit a robust innate immune response and inflammatory responses. Improvement of the therapeutic index of Ad vector gene therapy requires elucidation of the mechanism of Ad vector-induced inflammation and cytokine/chemokine production as well as development of the safer vector. In the present study, we found that the fiber-modified Ad vector containing poly-lysine peptides in… Expand
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