Fiber Formation across the Bacterial Outer Membrane by the Chaperone/Usher Pathway

@article{Remaut2008FiberFA,
  title={Fiber Formation across the Bacterial Outer Membrane by the Chaperone/Usher Pathway},
  author={Han Remaut and Chunyan Tang and Nadine S. Henderson and Jerome S Pinkner and Tian J. Wang and Scott J Hultgren and David G Thanassi and Gabriel Waksman and Huilin Li},
  journal={Cell},
  year={2008},
  volume={133},
  pages={640-652}
}
Gram-negative pathogens commonly exhibit adhesive pili on their surfaces that mediate specific attachment to the host. A major class of pili is assembled via the chaperone/usher pathway. Here, the structural basis for pilus fiber assembly and secretion performed by the outer membrane assembly platform--the usher--is revealed by the crystal structure of the translocation domain of the P pilus usher PapC and single particle cryo-electron microscopy imaging of the FimD usher bound to a… CONTINUE READING
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