Fhit, a putative tumor suppressor in humans, is a dinucleoside 5',5"'-P1,P3-triphosphate hydrolase.

@article{Barnes1996FhitAP,
  title={Fhit, a putative tumor suppressor in humans, is a dinucleoside 5',5"'-P1,P3-triphosphate hydrolase.},
  author={L. D. Barnes and P. Garrison and Z. Siprashvili and A. Guranowski and A. K. Robinson and S. W. Ingram and C. Croce and M. Ohta and K. Huebner},
  journal={Biochemistry},
  year={1996},
  volume={35 36},
  pages={
          11529-35
        }
}
Human Fhit (fragile histidine triad) protein, encoded by the FHIT putative tumor suppressor gene, is a typical dinucleoside 5',5"'-P1,P3-triphosphate (Ap3A) hydrolase (EC 3.6.1.29) on the basis of its enzymatic properties we report here. Ap3A is the preferred substrate among ApnA (n = 3-6), and AMP is always one of the reaction products. Mn2+ and Mg2+ are equally stimulatory, while Zn2+ is inhibitory with Ap3A as the substrate. Values of the K(m) for Ap3A and Ap4A are 1.3 and 4.6 microM… Expand
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Advances in Brief The Fhit Tumor Suppressor Protein Regulates the Intracellular Concentration of Diadenosine Triphosphate but not Diadenosine Tetraphosphate 1
To determine the role of theFHIT tumor suppressor gene product, a diadenosine 5*,5--P,P-triphosphate (Ap3A) hydrolase, in the regulation of the concentration of Ap3A and diadenosine 5*,5--PExpand
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This approach may provide a comparative framework for further investigation of FHIT, and gather information is known about biological activities of FhIT, the structural and biochemical bases for their functions. Expand
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