Fgfr1 regulates development through the combinatorial use of signaling proteins.

@article{Brewer2015Fgfr1RD,
  title={Fgfr1 regulates development through the combinatorial use of signaling proteins.},
  author={Joseph R. Brewer and Andrei Molotkov and Pierre Mazot and Ren{\'e}e V Hoch and Philippe Soriano},
  journal={Genes & development},
  year={2015},
  volume={29 17},
  pages={1863-74}
}
Fibroblast growth factor (Fgf) signaling governs multiple processes important in development and disease. Many lines of evidence have implicated Erk1/2 signaling induced through Frs2 as the predominant effector pathway downstream from Fgf receptors (Fgfrs), but these receptors can also signal through other mechanisms. To explore the functional significance of the full range of signaling downstream from Fgfrs in mice, we engineered an allelic series of knock-in point mutations designed to… CONTINUE READING