Fgf8 expression defines a morphogenetic center required for olfactory neurogenesis and nasal cavity development in the mouse.

@article{Kawauchi2005Fgf8ED,
  title={Fgf8 expression defines a morphogenetic center required for olfactory neurogenesis and nasal cavity development in the mouse.},
  author={Shimako Kawauchi and Jianyong Shou and Rosaysela Santos and Jean M H{\'e}bert and Susan K. McConnell and Ivor Mason and Anne L. Calof},
  journal={Development},
  year={2005},
  volume={132 23},
  pages={5211-23}
}
In vertebrate olfactory epithelium (OE), neurogenesis proceeds continuously, suggesting that endogenous signals support survival and proliferation of stem and progenitor cells. We used a genetic approach to test the hypothesis that Fgf8 plays such a role in developing OE. In young embryos, Fgf8 RNA is expressed in the rim of the invaginating nasal pit (NP), in a small domain of cells that overlaps partially with that of putative OE neural stem cells later in gestation. In mutant mice in which… CONTINUE READING