Fgf8 and Fgf3 are required for zebrafish ear placode induction, maintenance and inner ear patterning

@article{Lger2002Fgf8AF,
  title={Fgf8 and Fgf3 are required for zebrafish ear placode induction, maintenance and inner ear patterning},
  author={Sophie L{\'e}ger and Michael Brand},
  journal={Mechanisms of Development},
  year={2002},
  volume={119},
  pages={91-108}
}
The vertebrate inner ear develops from initially 'simple' ectodermal placode and vesicle stages into the complex three-dimensional structure which is necessary for the senses of hearing and equilibrium. Although the main morphological events in vertebrate inner ear development are known, the genetic mechanisms controlling them are scarcely understood. Previous studies have suggested that the otic placode is induced by signals from the chordamesoderm and the hindbrain, notably by fibroblast… CONTINUE READING
Highly Influential
This paper has highly influenced 13 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 92 extracted citations

Fgf-signaling-dependent Sox9a and Atoh1a regulate otic neural development in zebrafish.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2015
View 5 Excerpts
Highly Influenced

Hindbrain signals in otic regionalization: walk on the wild side.

The International journal of developmental biology • 2007
View 4 Excerpts
Highly Influenced

The first steps towards hearing: mechanisms of otic placode induction.

The International journal of developmental biology • 2007
View 5 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 105 references

Expression of a new zebrafish inner ear and lateral line specific gene, Nkx5-1, is significantly reduced in the ears of Fgf8 mutant, ace

M. Adamska, S. Legér, M. Brand, T. Hadrys, E. Bober
Mech. Dev • 2000
View 5 Excerpts
Highly Influenced

The zebrafish eya1 gene and its expression pattern during embryogenesis

Development Genes and Evolution • 1999
View 4 Excerpts
Highly Influenced

Early embryology of the vertebrate ear

B. Fritzsch, K. F. Barald, M. I. Lomax
Development of the Auditory System, • 1998
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…