Fgf10 is essential for limb and lung formation

@article{Sekine1999Fgf10IE,
  title={Fgf10 is essential for limb and lung formation},
  author={Keisuke Sekine and Hideyo Ohuchi and Masanori Fujiwara and Masahiro Yamasaki and Tatsuya Yoshizawa and Takashi Sato and Naoko Yagishita and Daisuke Matsui and Yoshihiko Koga and Nobuyuki Itoh and Shigeaki Kato},
  journal={Nature Genetics},
  year={1999},
  volume={21},
  pages={138-141}
}
The interactions between fibroblast growth factors (FGF) and their receptors have important roles in mediating mesenchymal-epithelial cell interactions during embryogenesis. In particular, Fgf10 is predicted to function as a regulator of brain, lung and limb development on the basis of its spatiotemporal expression pattern in the developing embryo. To define the role of Fgf10, we generated Fgf10-deficient mice. Fgf10-/- mice died at birth due to the lack of lung development. Trachea was formed… 
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TLDR
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FGF10 maintains distal lung bud epithelium and excessive signaling leads to progenitor state arrest, distalization, and goblet cell metaplasia
TLDR
It is concluded that FGF 10 inhibits terminal differentiation in the embryonic lung and maintains the distal epithelium, and that excessive levels of FGF10 leads to metaplastic differentiation of goblet cells similar to that seen in chronic inflammatory diseases.
Requirements for FGF3 and FGF10 during inner ear formation
TLDR
Double mutant mice are created for FGF3 and FGF10, which form severely reduced otic vesicles, suggesting redundant roles of these FGFs, acting in combination as neural signals for oic vesicle formation.
The dominant hemimelia mutation uncouples epithelial-mesenchymal interactions and disrupts anterior mesenchyme formation in mouse hindlimbs.
TLDR
It is shown here that the mouse mutation dominant hemimelia (Dh) alters the pattern of gene expression in the AER such that Fgf4, which is normally expressed in a posterior domain, and FgF8, who are expressed throughout are expressed in anterior patterns.
Discordant roles for FGF ligands in lung branching morphogenesis between human and mouse
TLDR
It is demonstrated that FGF7 and FGF9 had similar effects on human fetal lung as on mouse fetal lung; however, FGF10 caused the human explants to expand and form cysts as opposed to inducing epithelial branching as seen in the mouse.
Conditional gene inactivation reveals roles for Fgf10 and Fgfr2 in establishing a normal pattern of epithelial branching in the mouse lung
TLDR
The results indicate that both Fgf10 and Fgfr2 are required for a normal branching program and for proper proximal–distal patterning of the lung.
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TLDR
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