Fgf10 is essential for limb and lung formation

@article{Sekine1999Fgf10IE,
  title={Fgf10 is essential for limb and lung formation},
  author={Keisuke Sekine and Hideyo Ohuchi and Masanori Fujiwara and Masahiro Yamasaki and Tatsuya Yoshizawa and Takashi Sato and Naoko Yagishita and Daisuke Matsui and Yoshihiko Koga and Nobuyuki Itoh and Shigeaki Kato},
  journal={Nature Genetics},
  year={1999},
  volume={21},
  pages={138-141}
}
The interactions between fibroblast growth factors (FGF) and their receptors have important roles in mediating mesenchymal-epithelial cell interactions during embryogenesis. In particular, Fgf10 is predicted to function as a regulator of brain, lung and limb development on the basis of its spatiotemporal expression pattern in the developing embryo. To define the role of Fgf10, we generated Fgf10-deficient mice. Fgf10-/- mice died at birth due to the lack of lung development. Trachea was formed… 
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TLDR
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References

SHOWING 1-10 OF 32 REFERENCES
Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless.
TLDR
Although tracheal development was normal, main-stem bronchial formation, as well as all subsequent pulmonary branching morphogenesis, was completely disrupted, the pulmonary phenotype of Fgf-10(-/-) mice is strikingly similar to that of the Drosophila mutant branchless, an Ff homolog.
Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung.
TLDR
It is concluded that, during early lung development, localized sources of FGF10 in the mesoderm regulate endoderm proliferation and bud outgrowth.
Involvement of FGF-8 in initiation, outgrowth and patterning of the vertebrate limb.
The mesenchymal factor, FGF10, initiates and maintains the outgrowth of the chick limb bud through interaction with FGF8, an apical ectodermal factor.
TLDR
Evidence that a member of the fibroblast growth factor (FGF) family emanates from the prospective limb mesoderm to serve as an endogenous initiator for limb bud formation is provided and results suggest that FGF10 is a key mesenchymal factor involved in the initial budding as well as the continuous outgrowth of vertebrate limbs.
Roles for FGF8 in the Induction, Initiation, and Maintenance of Chick Limb Development
Targeted expression of a dominant negative FGF receptor blocks branching morphogenesis and epithelial differentiation of the mouse lung.
TLDR
To block the function ofFGFR2 during branching morphogenesis of the lung without affecting its function in other embryonic tissues, the human surfactant protein C promoter was used to target expression of a dominant negative FGFR2 exclusively to lung bud epithelium in transgenic mice.
Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis.
TLDR
A role for Sonic hedgehog in lung morphogenesis is established, and it is suggested that SHH normally regulates lung mesenchymal cell proliferation in vivo.
Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction.
TLDR
Findings provide direct genetic evidence that FGF/FGFR2 signals are absolutely required for vertebrate limb induction and that an FGFR2 signal is essential for the reciprocal regulation loop between FGF8 and FGF10 during limb induction.
Sonic hedgehog regulates branching morphogenesis in the mammalian lung
The roles of FGFs in the early development of vertebrate limbs.
TLDR
The purpose of this review is to discuss the functions performed by members of the FGF family in one of the best-studied vertebrate developmental systems—limb formation and discusses the potential role of FGFs in the induction of limb development.
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