Fgf10 is essential for limb and lung formation

@article{Sekine1999Fgf10IE,
  title={Fgf10 is essential for limb and lung formation},
  author={Keisuke Sekine and Hideyo Ohuchi and Masanori Fujiwara and Masahiro Yamasaki and Tatsuya Yoshizawa and Takashi Sato and Naoko Yagishita and Daisuke Matsui and Yoshihiko Koga and Nobuyuki Itoh and Shigeaki Kato},
  journal={Nature Genetics},
  year={1999},
  volume={21},
  pages={138-141}
}
The interactions between fibroblast growth factors (FGF) and their receptors have important roles in mediating mesenchymal-epithelial cell interactions during embryogenesis. In particular, Fgf10 is predicted to function as a regulator of brain, lung and limb development on the basis of its spatiotemporal expression pattern in the developing embryo. To define the role of Fgf10, we generated Fgf10-deficient mice. Fgf10-/- mice died at birth due to the lack of lung development. Trachea was formed… 
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TLDR
Although tracheal development was normal, main-stem bronchial formation, as well as all subsequent pulmonary branching morphogenesis, was completely disrupted, the pulmonary phenotype of Fgf-10(-/-) mice is strikingly similar to that of the Drosophila mutant branchless, an Ff homolog.
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TLDR
It is concluded that, during early lung development, localized sources of FGF10 in the mesoderm regulate endoderm proliferation and bud outgrowth.
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TLDR
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TLDR
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TLDR
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TLDR
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