Fgf signalling is required for formation of cartilage in the head.

@article{Walshe2003FgfSI,
  title={Fgf signalling is required for formation of cartilage in the head.},
  author={Jennifer Walshe and Ivor Mason},
  journal={Developmental biology},
  year={2003},
  volume={264 2},
  pages={522-36}
}
Characterisation of human craniofacial syndromes and studies in transgenic mice have demonstrated the requirement for Fgf signalling during morphogenesis of membrane bone of the cranium. Here, we report that Fgf activity is also required for development of the oro-pharyngeal skeleton, which develops first as cartilage with some elements subsequently becoming ossified. We show that inhibition of FGF receptor activity in the zebrafish embryo following neural crest emigration from the neural tube… CONTINUE READING