Fgf-2 overexpression increases excitability and seizure susceptibility but decreases seizure-induced cell loss.

Abstract

Fibroblast growth factor 2 (FGF-2) has multiple, pleiotropic effects on the nervous system that include neurogenesis, neuroprotection and neuroplasticity. Thus, alteration in FGF-2 expression patterns may have a profound impact in brain function, both in normal physiology and in pathology. Here, we used FGF-2 transgenic mice (TgFGF2) to study the effects of… (More)
DOI: 10.1523/JNEUROSCI.1472-08.2008

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Cite this paper

@article{Zucchini2008Fgf2OI, title={Fgf-2 overexpression increases excitability and seizure susceptibility but decreases seizure-induced cell loss.}, author={Silvia Zucchini and Andrea Buzzi and Mario Barbieri and Donata Rodi and Beatrice Paradiso and Anna Binaschi and J. Douglas Coffin and Andrea Marzola and Pierangelo Cifelli and Ottorino Belluzzi and Michele Simonato}, journal={The Journal of neuroscience : the official journal of the Society for Neuroscience}, year={2008}, volume={28 49}, pages={13112-24} }