Fezf2 directs the differentiation of corticofugal neurons from striatal progenitors in vivo

Abstract

In the developing cerebral cortex, cell-extrinsic and cell-intrinsic signals govern the establishment of neuron subtype-specific identity. Here we show that, within the niche of the striatum, the expression of a single transcription factor, Fezf2, is sufficient to generate corticofugal neurons from progenitors fated to become medium spiny neurons. This demonstrates that a specific population of cortical projection neurons can be directed to differentiate outside of the cortex by cell-autonomous signaling.

DOI: 10.1038/nn.2658

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@article{Rouaux2010Fezf2DT, title={Fezf2 directs the differentiation of corticofugal neurons from striatal progenitors in vivo}, author={Caroline Rouaux and Paola Arlotta}, journal={Nature Neuroscience}, year={2010}, volume={13}, pages={1345-1347} }