Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development.

@article{Vecchione2007Fez1Lzts1AI,
  title={Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development.},
  author={Andrea Vecchione and Gustavo Baldassarre and Hideshi Ishii and Milena Sabrina Nicoloso and Barbara Belletti and Fabio Petrocca and Nicola Zanesi and Louise Y. Fong and Sabrina Battista and Daniela Guarnieri and Raffaele Baffa and Hansjuerg Alder and John L. Farber and Peter J Donovan and Carlo M. Croce},
  journal={Cancer cell},
  year={2007},
  volume={11 3},
  pages={275-89}
}
The FEZ1/LZTS1 (LZTS1) protein is frequently downregulated in human cancers of different histotypes. LZTS1 is expressed in normal tissues, and its introduction in cancer cells inhibits cell growth and suppresses tumorigenicity, owing to an accumulation of cells in G2/M. Here, we define its role in cell cycle regulation and tumor progression by generating Lzts1 knockout mice. In Lzts1(-/-) mouse embryo fibroblasts (MEFs), Cdc25C degradation was increased during M phase, resulting in decreased… CONTINUE READING

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