Fez family transcription factors: controlling neurogenesis and cell fate in the developing mammalian nervous system.

@article{Eckler2014FezFT,
  title={Fez family transcription factors: controlling neurogenesis and cell fate in the developing mammalian nervous system.},
  author={Matthew J. Eckler and Bingguang Chen},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  year={2014},
  volume={36 8},
  pages={788-97}
}
Fezf1 and Fezf2 are highly conserved transcription factors that were first identified by their specific expression in the anterior neuroepithelium of Xenopus and zebrafish embryos. These proteins share an N-terminal domain with homology to the canonical engrailed repressor motif and a C-terminal DNA binding domain containing six C2H2 zinc-finger repeats. Over a decade of study indicates that the Fez proteins play critical roles during nervous system development in species as diverse as fruit… CONTINUE READING
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