Fewer chromosome aberrations and earlier apoptosis induced by DNA synthesis inhibitors, a topoisomerase II inhibitor or alkylating agents in human cells with normal compared with mutant p53.

@article{Greenwood1998FewerCA,
  title={Fewer chromosome aberrations and earlier apoptosis induced by DNA synthesis inhibitors, a topoisomerase II inhibitor or alkylating agents in human cells with normal compared with mutant p53.},
  author={Susan K Greenwood and Michael J. Armstrong and Rosina B Hill and C I Bradt and Timothy E. Johnson and Cathy Hilliard and Sheila M. Galloway},
  journal={Mutation research},
  year={1998},
  volume={401 1-2},
  pages={39-53}
}
The human lymphoblastoid cell lines TK6 (normal p53) and WI-L2-NS or WTK1 (mutant p53) differ in sensitivity to killing and induction of gene mutations and chromosome aberrations by ionizing radiation. This may be related to decreased apoptosis in the cells with mutated p53, such that more damaged cells survive. We compared the response of the two cell types to various chemicals. First, to ensure that the thymidine kinase deficiency does not increase the sensitivity of TK6 tk+/- cells to… CONTINUE READING

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