Few things in life are "free": cellular uptake of steroid hormones by an active transport mechanism.

@article{Lin2005FewTI,
  title={Few things in life are "free": cellular uptake of steroid hormones by an active transport mechanism.},
  author={Benjamin C. Lin and Thomas S. Scanlan},
  journal={Molecular interventions},
  year={2005},
  volume={5 6},
  pages={338-40}
}
Conventional dogma holds that steroid hormones traverse cell membranes passively, owing to their lipophilic nature. The recently characterized protein megalin, however, functions as a transport protein on cell surfaces to carry steroids across the plasma membrane. Upon hydrolysis of steroid-associated binding globulins in lysosomes, free hormone is liberated and may exert its effects in the cell. Megalin-independent mechanisms of steroid uptake are likely important too, as the phenotypes of… CONTINUE READING
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