• DOI:10.1517/14712598.5.9.1147
Corpus ID: 8626116

Feverfew: weeding out the root of leukaemia

@article{Guzman2005FeverfewWO,
  title={Feverfew: weeding out the root of leukaemia},
  author={M. Guzman and C. T. Jordan},
  journal={Expert Opinion on Biological Therapy},
  year={2005},
  volume={5},
  pages={1147 - 1152}
}

M. Guzman, C. T. Jordan

Published 2005

Biology, Medicine

Expert Opinion on Biological Therapy

Malignant stem cells are central to the pathogenesis and perpetuation of acute myelogenous leukaemia (AML). Despite their crucial role, standard chemotherapy often does not target these critical cells and, thus, the ‘root’ of leukaemic disease is not eradicated. To derive better therapies, unique molecular features of malignant stem cells have been characterised for AML and evaluated with regard to ablation of disease. In the course of such studies, the compound parthenolide, which is derived… CONTINUE READING

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