Feverfew: weeding out the root of leukaemia

  title={Feverfew: weeding out the root of leukaemia},
  author={M. Guzman and C. T. Jordan},
  journal={Expert Opinion on Biological Therapy},
  pages={1147 - 1152}
  • M. Guzman, C. T. Jordan
  • Published 2005
  • Biology, Medicine
  • Expert Opinion on Biological Therapy
  • Malignant stem cells are central to the pathogenesis and perpetuation of acute myelogenous leukaemia (AML). Despite their crucial role, standard chemotherapy often does not target these critical cells and, thus, the ‘root’ of leukaemic disease is not eradicated. To derive better therapies, unique molecular features of malignant stem cells have been characterised for AML and evaluated with regard to ablation of disease. In the course of such studies, the compound parthenolide, which is derived… CONTINUE READING
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