Feverfew: weeding out the root of leukaemia

@article{Guzman2005FeverfewWO,
  title={Feverfew: weeding out the root of leukaemia},
  author={M. Guzman and C. T. Jordan},
  journal={Expert Opinion on Biological Therapy},
  year={2005},
  volume={5},
  pages={1147 - 1152}
}
  • M. Guzman, C. T. Jordan
  • Published 2005
  • Biology, Medicine
  • Expert Opinion on Biological Therapy
  • Malignant stem cells are central to the pathogenesis and perpetuation of acute myelogenous leukaemia (AML). Despite their crucial role, standard chemotherapy often does not target these critical cells and, thus, the ‘root’ of leukaemic disease is not eradicated. To derive better therapies, unique molecular features of malignant stem cells have been characterised for AML and evaluated with regard to ablation of disease. In the course of such studies, the compound parthenolide, which is derived… CONTINUE READING
    35 Citations

    Topics from this paper

    The leukemia stem cell.
    • Z. Estrov
    • Biology, Medicine
    • Cancer treatment and research
    • 2010
    • 2
    Parthenolide: from plant shoots to cancer roots.
    • 155
    Melampomagnolide B: a new antileukemic sesquiterpene.
    • 35
    Drugs that Kill Cancer Stem-like Cells
    • 3
    • PDF
    Redox control of leukemia: from molecular mechanisms to therapeutic opportunities.
    • 114

    References

    SHOWING 1-10 OF 54 REFERENCES
    The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells.
    • 593
    Preferential induction of apoptosis for primary human leukemic stem cells
    • 424
    • PDF
    Camptothecin and taxol: historic achievements in natural products research.
    • 275
    • PDF
    Characterization of acute lymphoblastic leukemia progenitor cells.
    • 250
    • PDF
    A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
    • 4,110
    • Highly Influential
    Oxidative Stress-mediated Apoptosis
    • 260
    • PDF
    Isolation of a highly quiescent subpopulation of primitive leukemic cells in chronic myeloid leukemia.
    • 512
    Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • 6,136
    • Highly Influential
    • PDF