Fever-range thermal stress promotes lymphocyte trafficking across high endothelial venules via an interleukin 6 trans-signaling mechanism

@article{Chen2006FeverrangeTS,
  title={Fever-range thermal stress promotes lymphocyte trafficking across high endothelial venules via an interleukin 6 trans-signaling mechanism},
  author={Qing Chen and Daniel T. Fisher and Kristen A Clancy and Jean-Marc M Gauguet and Wan-chao Wang and Emily Unger and Stefan Rose-John and Ulrich H. von Andrian and Heinz Baumann and Sharon S Evans},
  journal={Nature Immunology},
  year={2006},
  volume={7},
  pages={1299-1308}
}
Fever is an evolutionarily conserved response during acute inflammation, although its physiological benefit is poorly understood. Here we show thermal stress in the range of fever temperatures increased the intravascular display of two 'gatekeeper' homing molecules, intercellular adhesion molecule 1 (ICAM-1) and CCL21 chemokine, exclusively in high endothelial venules (HEVs) that are chief portals for the entry of blood-borne lymphocytes into lymphoid organs. Enhanced endothelial expression of… CONTINUE READING

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defining a role for IL-6

  • Jones, S. A. Directing transition from innate to acquired immunity
  • J. Immunol. 175, 3463–3468
  • 2005

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