Fever of recombinant human interferon-alpha is mediated by opioid domain interaction with opioid receptor inducing prostaglandin E2

@article{Wang2004FeverOR,
  title={Fever of recombinant human interferon-alpha is mediated by opioid domain interaction with opioid receptor inducing prostaglandin E2
},
  author={Yun-xia Wang and Weigang Xu and Xue-jun Sun and Yi-Zhang Chen and Xin-Yuan Liu and Hao Tang and Chun-Lei Jiang},
  journal={Journal of Neuroimmunology},
  year={2004},
  volume={156},
  pages={107-112}
}
We have reported that there are distinct domains in Interferon-alpha (IFNalpha) molecule mediating immune and opioid-like effects respectively. And the opioid effect of IFNalpha is mediated by mu opioid receptor. We report here the structural basis of fever induced by recombinant human IFNalpha. Two kinds of IFNalpha mutants were obtained and used to investigate the structural basis of fever of IFNalpha, which are 129Ser-IFNalpha and 38Leu-IFNalpha. The antiviral activity of 129Ser-IFNalpha… Expand
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These studies show strong structural and functional similarities between INFalpha and opioid peptides, and inferred that the analgesic domain locates around the 122nd Tyr residue of IFNalpha molecule in tertiary structure. Expand
Distinct domains of IFNα mediate immune and analgesic effects respectively
Abstract Interferon-alpha (IFNα) is not only an immunoregulatory factor, but is also an analgesic molecule. The analgesic effect of IFNα was mediated by μ opioid receptor. After the 129th Tyr residueExpand
Analgesic effect of interferon-alpha via mu opioid receptor in the rat
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The evidence is consistent with the hypothesis that multiple actions of cytokines, such as immunoregulatory and neuroregulatory effects, might be mediated by distinct domains of cytokine interacting with different receptors. Expand
Analgesic domains of interferon-α
Interferon-α (IFNα) is not only an immunoregulatory factor, but is also an analgesic molecule. We ever reported that there exist distinct domains in IFNα molecule that mediate immune and analgesicExpand
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Results suggest that systemic and central elements of the opioid system may play differential roles in temperature regulation and previous administration of NLX and IFN-alpha 2b may alter the sensitivity of the CNS to subsequent injections of different pyrogens. Expand
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Detailed whole-cell clamping analyses on neuronal mechanisms in rat brain tissue slices showed that the inhibitory effect of rhIFN-α on N-methyl-D-aspartate-induced membrane current responses of MPO neurons was mediated not only by opioid receptors but also by the local production of reactive oxygen intermediates, nitric oxide and prostanoids, possibly due to neuron-glial cell interaction. Expand
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The results suggest that an opioid that its involvement may last only in the early phase of the fever, but not after the plateau has been reached. Expand
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