Fever of recombinant human interferon-alpha is mediated by opioid domain interaction with opioid receptor inducing prostaglandin E2

  title={Fever of recombinant human interferon-alpha is mediated by opioid domain interaction with opioid receptor inducing prostaglandin E2
  author={Yun-xia Wang and Weigang Xu and Xue-jun Sun and Yi-Zhang Chen and Xin-Yuan Liu and Hao Tang and Chun-Lei Jiang},
  journal={Journal of Neuroimmunology},

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  • E. M. SmithJ. Blalock
  • Biology, Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 1981
Almost 100% of the human peripheral lymphocytes were capable of producing both ACTH and gamma-endorphin-related substances, presumably associated with hIFN-alpha, which strongly suggest a circuit between the immune and neuroendocrine systems which involves neuroendocrin hormone-like substances.