Fever in Children and Fever of Unknown Origin

  title={Fever in Children and Fever of Unknown Origin},
  author={Rajeshwar Dayal and Dipti Agarwal},
  journal={The Indian Journal of Pediatrics},
Fever is the most common symptom in children and can be classified as fever with or without focus. Fever without focus can be less than 7 d and is subclassified as fever without localizing signs and fever of unknown origin (FUO). FUO is defined as a temperature greater than 38.3 °C, for more than 3 wk or failure to reach a diagnosis after 1 wk of inpatient investigations. The most common causes of FUO in children are infections, connective tissue disorders and neoplasms. Infectious diseases… 
Etiology and clinical characteristics of fever of unknown origin in children: a 15-year experience in a single center
Investigation of the etiology, clinical characteristics and prognosis of pediatric FUO in 21 century with more diagnostics available and to analyze the factors for certain disease categories finds undiagnosed portion of F UO have now increased due to development of diagnostic techniques for infectious diseases.
Fever of unknown origin - a literature review.
The objective of this study is to review the main topics about fever of undetermined origin, bringing historical and scientific aspects, national and international, to review.
childhood fever of unknown origin ( FUO ) – a
  • Medicine
  • 2019
This case of childhood lupus presenting as FUO, multiple joint pain, uveitis, periphlebitis, without specific skin lesions, renal and hematological manifestations is reported, emphasizing the need for meticulous evaluation and long term follow up for children with FUo diagnosed as rheumatological illness.
Fever of unknown origin in special groups.
The initial diagnostic approach of the FUO patient should include non-specific complementary exams, and empirical therapy is not recommended (with few exceptions), as it may disguise and delay the diagnosis and conduct to treat the specific etiology.
Chromosomal abnormalities related to fever of unknown origin in a Chinese pediatric cohort and literature review
Investigation of the clinical and genetic characteristics of patients with FUO presenting with chromosomal abnormalities in a Chinese pediatric cohort found the important role of detecting chromosome abnormalities in patients withFUO is emphasized, especially in Patients with systemic inflammatory manifestations or developmental delay.
Etiology of fever of unknown origin in children.
Infectious diseases were the most common cause of FUO followed by malignancy, connective tissue disorders and miscellaneous causes, and there was a significant association between duration of fever and the ultimate diagnosis.
Fever without Focus in Children Aged 1 to 36 Months- Aetiological Profile and Predictors of Specific Aetiology- A Prospective Observational Study
SBI and DF were the most common causes of FWF.
TNFRSF1A gene variant identified in a boy with recurrent episodes of fever
A boy with recurrent fever of unknown origin who was by clinically guided partial exome sequencing found to have a heterozygous variant 434A>G in the TNFRSF1A gene, otherwise connected with tumor necrosis factor receptor-associated periodic fever syndrome is presented.
Pediatric Spinal Epidural Abscess: A Case Report of a 12-year-old Girl Without Risk Factors
Despite its irradiation to the patient, CT might be useful for providing an early diagnosis in the absence of neurologic symptoms, and whole-body CT later diagnosed a SEA, which was treated by antibiotics only.


Unexplained fever-analysis of 233 cases in a referral hospital.
A study was conducted to analyse the causes of fever of unknown origin (FUO) in a teaching hospital in central India. Study subjects consisted of 233 patients having FUO admitted in the medical ward.
Fever of Unknown Origin: An Evidence-Based Review
This review focuses on the key factors of classic FUO, and the etiologic clues obtainable from the history, bedside physical examination findings and pertinent laboratory tests are discussed.
Prolonged fever in children.
  • C. Chien, C. Lee, L. Huang
  • Medicine
    Zhonghua Minguo xiao er ke yi xue hui za zhi [Journal]. Zhonghua Minguo xiao er ke yi xue hui
  • 1996
During a four-year period, 86 children with fever lasting for at least 6 days without diagnosis at admission after initial physical examination and preliminary laboratory tests were included in a
Prolonged fever of unknown origin in children.
  • H. J. Mcclung
  • Medicine
    American journal of diseases of children
  • 1972
All admissions for a ten-year period were reviewed to determine the nature of illnesses which appeared at a referral center in the form of a prolonged fever of unknown origin, and nine children were found to be completely normal physically.
Approach to the adult patient with fever of unknown origin.
A thorough history, physical examination, and standard laboratory testing remain the basis of the initial evaluation of the patient with FUO, and newer diagnostic modalities have important roles in the assessment of these patients.
Fever of Unknown Origin in Turkey
Although the relative rate of infectious disease as etiologic category is less commonly encountered, infectious disease, especially tuberculosis, remains a common cause of FUO.
Prolonged fever in children: review of 100 cases.
Careful history and physical examinations were helpful but the usual laboratory data were notably disappointing; however, sedimentation rates and serum protein electrophoresis were often reliable screening tests.
The Role of Invasive and Non-Invasive Procedures in Diagnosing Fever of Unknown Origin
Clinical features (such as detailed medical history-taking and physical examination) may contribute to diagnoses, particularly in cases of collagen vascular diseases, as well as imaging studies exhibit certain pathologies that guide invasive studies.
Fever of unknown origin: focused diagnostic approach based on clinical clues from the history, physical examination, and laboratory tests.
  • B. Cunha
  • Medicine
    Infectious disease clinics of North America
  • 2007
The Yield of a Structured Diagnostic Protocol
Significant predictors for reaching a diagnosis included continuous fever; fever present for <180 days; elevated erythrocyte sedimentation rate, C-reactive protein, or lactate dehydrogenase; leukopenia; thrombocytosis; abnormal chest computed tomography (CT); and abnormal F-fluorodeoxyglucose positron emission tomographic (FDG-PET).