Fever following immunization

  title={Fever following immunization},
  author={Terhi Tapiainen and Ulrich Heininger},
  journal={Expert Review of Vaccines},
  pages={419 - 427}
Fever is a frequent systemic adverse event following immunization, especially in infants and young children. Any fever after immunization may be caused by immunization or may coincide temporally as an indication of underlying disease, usually an infectious one. The time pattern of fever attributable to immunization has characteristic features depending on the vaccine used. Comparability of fever rates associated with different vaccines, or the same vaccines in different studies, is frequently… 

Perception and management of fever in infants up to six months of age: A survey of US pediatricans

Recommendations for the management of fever in infants are likely to depend on fever severity level, the infant age, timing in relation to recent vaccination, and the time of day fever is reported.

Comparison of Postvaccination Fever between Single and Multiple Vaccines using Patient-Generated Health Data: A Retrospective Observational Study (Preprint)

Investigating the postvaccination fever patterns of six vaccines recommended for children aged 2-6 months in the National Immunization Program of Korea found multiple vaccinations did not induce more severe fever or have rapid onset compared with a single vaccination.

Comparison of the immunogenicity and safety of 3 inactivated hepatitis A vaccines in Korean children aged 12 to 18 months

The results indicate that the most commonly used inactivated hepatitis A vaccines were safe and immunogenic in ethnic Korean children and will be informative to countries that plan to initiate vaccination programs against HAV.

Vaccination in Elite Athletes

Very few discipline-specific considerations apply to an athlete’s vaccination schedule mainly from the competition and training pattern as well as from the typical geographical distribution of competitive sites.

Fever and breast cancer: A critical review of the literature and possible underlying mechanisms.

The efficacy of non-steroidal anti-inflammatory drugs was discussed as a therapeutic option to control postoperative fever and the chemotherapy-induced neutropenic fever and cancer vaccination-induced fever were reviewed.

Immunogenicity and Safety of an Inactivated SARS-CoV-2 Vaccine: Preclinical Studies

A whole virus NRC-VACC-01 inactivated candidate SARS-CoV-2 vaccine was developed and tested its safety and immunogenicity in laboratory animals and it was revealed that the vaccine was highly tolerable.

Limitations of the rabbit pyrogen test for assessing meningococcal OMV based vaccines.

The rabbit pyrogen test was developed in the early 1900's to detect contaminating pyrogens in parenteral medicines but is unsuitable as a safety test for these products due to the high levels of endotoxin present in the vaccine.



Unexplained fever in young children: how to manage severe bacterial infection

  • I. Brook
  • Medicine
    BMJ : British Medical Journal
  • 2003
The bacterial causes, essential diagnostic tests, clinical assessment, judicious use of antibiotics, and follow up in unexplained, difficult to diagnose bacterial infection causing fever in young children are discussed.

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The frequency of serious neurologic events following the administration of 106,000 doses of diphtheria-tetanus-pertussis vaccine at Group Health Cooperative of Puget Sound was determined using a

Association of reactions after consecutive acellular or whole-cell pertussis vaccine immunizations.

Reactions after a second or third immunization with either WCL or DTaP vaccine are more likely to occur in infants who had the same reaction after the preceding immunization.

MMR vaccination and febrile seizures: evaluation of susceptible subgroups and long-term prognosis.

CONTEXT The rate of febrile seizures increases following measles, mumps, and rubella (MMR) vaccination but it is unknown whether the rate varies according to personal or family history of seizures,

Varicella vaccine studies in healthy children and adults.

Clinical trials designed to obtain information on minimum dose immunogenicity pre- and postexposure prophylaxis, immunization of various age groups, and booster immunizations for seropositive individuals documented a 94% to 100% seroconversion rate and persistence of antibodies at 3 to 4 years.

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Comparison of 13 acellular pertussis vaccines: adverse reactions.

Although there were differences among the acellular vaccines, none was consistently the most or least reactogenic; all were associated with substantially fewer and less severe adverse reactions than a standard commercial whole-cell vaccine.

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