Sickness behavior in feverish children is independent of the severity of fever. An observational, multicenter study
- Medicine, PsychologyPloS one
It is suggested that sickness behavior (SB) and fever are two independent manifestations that are activated simultaneously during an infection.
Let fever do its job
- MedicineEvolution, medicine, and public health
For infections with novel SARS-CoV-2, the precautionary principle applies: unless evidence suggests otherwise, that fever should be allowed to run its course, and the benefits of allowing fever to occur probably outweigh its harms.
Inflammation, fever, and body temperature under febrile conditions
- BiologyJournal of basic and clinical physiology and pharmacology
Fever and other characteristic symptoms of sickness occur as rather stereotyped physiological and behavioral responses that are controlled by specific neuronal circuitries within the brain, and induction of these symptoms depends on a propagation of the inflammatory response from the periphery into the brain.
Fever as an important resource for infectious diseases research.
- Biology, MedicineIntractable & rare diseases research
Evidence is presented that the temperature increase during fever affects the way the infection takes place, for both the pathogen and the host.
Reverse Engineering the Febrile System
- BiologyThe Quarterly Review of Biology
It is shown that natural selection appears to have modified several immune system effects to be coordinated by fever, and it is argued that there are some adaptations that coordinate the febrile system with other important fitness components, particularly growth and reproduction.
Fever and antipyretic therapy in the septic patient in the intensive care unit: an update
- Medicine, BiologyBoletín Médico del Hospital Infantil de México (English Edition)
Fever is a very common sign to observe in critically ill children during their intensive care unit stay and antipyretic therapy is commonly employed and human studies on the presence of fever and its treatment for the prognosis of critically ill septic patients are inconclusive.
Simvastatin attenuated sickness behavior and fever in a murine model of endotoxemia.
- Biology, MedicineLife sciences
Neural Mechanisms of Inflammation-Induced Fever
- Biology, MedicineThe Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
It is concluded that there is unequivocal evidence for a humoral signaling pathway by which proinflammatory cytokines, through their binding to receptors on brain endothelial cells, evoke fever by eliciting prostaglandin E2 synthesis in these cells.
Fevers and the social costs of acute infection in wild vervet monkeys
- BiologyProceedings of the National Academy of Sciences
A hidden cost of sociality is demonstrated: Febrile animals were twice as likely to receive aggression from their group mates and were six times more likely to be wounded following the onset of a fever, suggesting social transmission of infection within a group is likely.
SHOWING 1-10 OF 146 REFERENCES
Cytokine‐Induced Sickness Behavior: Mechanisms and Implications
- BiologyAnnals of the New York Academy of Sciences
There is evidence that the sickness motivational state can interact with other motivational states and respond to nonimmune stimuli probably by way of sensitization and/or classical conditioning, however, the mechanisms that are involved in plasticity of the Sickness motivational state are not yet understood.
Concepts of fever.
- MedicineArchives of internal medicine
The present review considers many of these issues in the light of current data concerning the role played by exogenous and endogenous pyrogens in the induction of fever and the existence of an equally complex and important system of endogenous cryogens.
Understanding the symptoms of the common cold and influenza
- MedicineThe Lancet Infectious Diseases
Mechanisms of fever production and lysis: lessons from experimental LPS fever.
- BiologyComprehensive Physiology
During the course of fever, counterinflammatory factors, "endogenous antipyretics," are elaborated peripherally and centrally to limit fever in strength and duration.
Fever and hypothermia in systemic inflammation: recent discoveries and revisions.
- BiologyFrontiers in bioscience : a journal and virtual library
It has been established that the same inflammatory agent can induce either fever or hypothermia, depending on several factors, and that different mechanisms underlie different febrile phases.
Clinical review: Fever in septic ICU patients - friend or foe?
- Medicine, BiologyCritical care
The advantages and drawbacks of fever in septic patients are delineated and the treatment of fever by pharmacological and/or physical means is discussed with regards to their drawbacks, which argues for their careful use in sepsis patients in the absence of clinical relevance.
Prostaglandins and sickness behavior: Old story, new insights
- BiologyPhysiology & Behavior
Population-level effects of suppressing fever
- MedicineProceedings of the Royal Society B: Biological Sciences
It is suggested that, overall, fever suppression increases the expected number of influenza cases and deaths in the US: for pandemic influenza with reproduction number , the estimated increase is 1% (95% CI: 0.0–2.7%), whereas for seasonal influenza with , the Estimated increase is 5% ( 95% CI): 0.2–12.1%).