Fever and cancer in perspective

@article{Hobohm2001FeverAC,
  title={Fever and cancer in perspective},
  author={Uwe Hobohm},
  journal={Cancer Immunology, Immunotherapy},
  year={2001},
  volume={50},
  pages={391-396}
}
  • U. Hobohm
  • Published 1 October 2001
  • Medicine
  • Cancer Immunology, Immunotherapy
Abstract.Context: A relationship between feverish infection and concurrent remission from cancer has been known about for a very long time. However, a systematic investigation of the phenomenon has not yet been made. Objective: To bring together the isolated observations about the coincidence of spontaneous remissions with feverish infections and William Coley's seminal work, as a basis for devising an immunological hypothesis about the putative anti-cancer effect of fever. Conclusion: Fever… 
Fever therapy revisited
  • U. Hobohm
  • Medicine, Biology
    British Journal of Cancer
  • 2005
The phenomenon of spontaneous regression and remission from cancer has been observed by many physicians and was described in hundreds of publications. However, suggestive clues on cause or trigger
Regression in cancer following fever and acute infection
TLDR
It is argued that acute infections especially when accompanied by high fever can induce and facilitate an effi cient antitumoral response, and may improve antitumor effiCacy of immunotherapy.
Fever in Cancer Treatment: Coley's Therapy and Epidemiologic Observations
  • G. Kienle
  • Medicine
    Global advances in health and medicine
  • 2012
TLDR
In the fall of 1890, an athletic, self-possessed, and thoughtful 17-year-old girl, who had just returned from an adventurous trip to Alaska, went to see a young, innovative surgeon in his new practice in New York City, and the young woman asked him for help with her poorly healing, swollen, and naggingly painful injury.
Toward general prophylactic cancer vaccination
  • U. Hobohm
  • Medicine, Biology
    BioEssays : news and reviews in molecular, cellular and developmental biology
  • 2009
TLDR
It is concluded that pathogenic substances belonging to the group of “pathogen‐associated molecular patterns” can trigger the innate immune system to establish anti‐neoplastic immune responses and might leverage considerable prophylactic potential.
Safety of Therapeutic Fever Induction in Cancer Patients Using Approved PAMP Drugs
Bacteria and cancer: cause, coincidence or cure? A review
  • DL Mager
  • Medicine, Biology
    Journal of Translational Medicine
  • 2006
TLDR
Bacterial species and their roles in particular cancers appear to differ among different individuals, and this critical factor may lead to the development of non-invasive diagnostic tests, innovative treatments and cancer vaccines.
Fever and the use of paracetamol during IL-2-based immunotherapy in metastatic melanoma
TLDR
It is suggested high fever as a biomarker for improved survival in melanoma patients treated with IL-2/IFN and the routine use of fever-reducing drugs during immunotherapy can be questioned.
Bacterial Preparations
TLDR
In this chapter, various bacterial preparations that have been applied for tumor immunotherapy will be introduced, together with the new detailed mechanism of action of those two immune systems that have recently been elucidated.
...
...

References

SHOWING 1-10 OF 37 REFERENCES
Spontaneous Regression of Cancer
TLDR
It is submitted that the findings do not warrant the sweeping generalizations that are made in relation to the complex problems of cerebrovascular stenosis and to the equally potentially catastrophic states of hypertension, and that the word " ischaemic" in the title of the paper is questioned.
Coley toxins immunotherapy: a retrospective review.
TLDR
It is suggested that patients treated with surgery and Coley toxins between 1890 and 1960 experienced survival rates comparable to those of patients diagnosed in 1983 and treated with nonradiotherapeutic conventional approaches.
The spontaneous regression of cancer. A review of cases from 1900 to 1987.
TLDR
It is concluded that the literature on the spontaneous regression of cancer is still unable to provide unambiguous accounts of the mechanisms operating to affect these regressions.
End results in reticulum cell sarcoma of bone treated by bacterial toxin therapy alone or combined with surgery and/or radiotherapy (47 cases) or with concurrent infection (5 cases)
TLDR
The evidence suggests that the most important factors were the stage and extent of the disease at onset of toxin therapy, the timing and dosage of radiotherapy, and the technique of toxin administration.
Coley's toxins in perspective
Despite initial hopes, the efficacy of tumour necrosis factor in treating cancer patients has been disappointing. But a more careful selection of patients, and more appropriate treatment, might be
Clinical results and immunologic effects of a mixed bacterial vaccine in cancer patients
TLDR
MBV is a well-tolerated biological response modifier with modest activity in advanced human tumors, and a patient with AIDS and Kaposi’s sarcoma experienced a dramatic improvement in performance status and disease stabilization.
Effect of the mixed bacterial vaccine on the immune response of patients with non‐small cell lung cancer and refractory malignancies
TLDR
In this pilot study, cancer patients treated with MBV showed objective evidence of immune stimulation with acceptable toxicity, and some patients, B‐cells and helper T‐cell populations increased, whereas T‐suppressor cell numbers declined.
Meta-analysis of Adjuvant Immunochemotherapy Using OK-432 in Patients With Resected Non-Small-Cell Lung Cancer
TLDR
It is postulated that postoperative adjuvant immunochemotherapy using OK-432 might improve the survival of patients after resection of non–small-cell lung cancer through a meta-analysis of data from 1,520 patients enrolled in 11 randomized clinical trials.
Spontaneous Regression of Advanced Malignant Melanoma
TLDR
The histologic confirmation of malignancy in cutaneous and subcutaneous nodules is documented in most cases and the spontaneous regression of metastasizing melanomas is a spectacular event.
...
...