Fever Is Mediated by Conversion of Endocannabinoid 2-Arachidonoylglycerol to Prostaglandin E2

Abstract

Fever is a common response to inflammation and infection. The mechanism involves prostaglandin E2 (PGE2)-EP3 receptor signaling in the hypothalamus, which raises the set point of hypothalamic thermostat for body temperature, but the lipid metabolic pathway for pyretic PGE2 production remains unknown. To reveal the molecular basis of fever initiation, we… (More)
DOI: 10.1371/journal.pone.0133663

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Cite this paper

@inproceedings{Kita2015FeverIM, title={Fever Is Mediated by Conversion of Endocannabinoid 2-Arachidonoylglycerol to Prostaglandin E2}, author={Yoshihiro Kita and Kenij Yoshida and Suzumi M. Tokuoka and Fumie Hamano and Maya Yamazaki and Kenji Sakimura and Masanobu Kano and Takao Shimizu and Andrej A. Romanovsky}, booktitle={PloS one}, year={2015} }