Fever, Cancer Incidence and Spontaneous Remissions

@article{Kleef2001FeverCI,
  title={Fever, Cancer Incidence and Spontaneous Remissions},
  author={Ralf Kleef and Wayne B Jonas and Wolfgang Knogler and W. Stenzinger},
  journal={Neuroimmunomodulation},
  year={2001},
  volume={9},
  pages={55 - 64}
}
Objective: Accumulating evidence exists for (1) an inverse correlation between the incidence of infectious diseases and cancer risk and (2) an inverse correlation between febrile infections and remissions of malignancies. [] Key Method Results: The data reviewed in this article support earlier observations on the topic, i.e. that the occurrence of fever in childhood or adulthood may protect against the later onset of malignant disease and that spontaneous remissions are often preceded by feverish infections…
View on PubMed
samueliinstitute.org
52 Citations
Highly Influential Citations
2
Background Citations
18

Figures and Tables from this paper

52 Citations

Citation Type

Citation Type

Regression in cancer following fever and acute infection
TLDR
It is argued that acute infections especially when accompanied by high fever can induce and facilitate an effi cient antitumoral response, and may improve antitumor effiCacy of immunotherapy.
Fever, Pyrogens and Cancer
TLDR
Though the biological effects of fever on tumors are well characterized and interesting biological and immune ological results are obtained, and some clinical observational studies and small randomized trials show very promising results, larger controlled GCP-conform trials are still lacking.
Acute infections as a means of cancer prevention: opposing effects to chronic infections?
Fever and the use of paracetamol during IL-2-based immunotherapy in metastatic melanoma
TLDR
It is suggested high fever as a biomarker for improved survival in melanoma patients treated with IL-2/IFN and the routine use of fever-reducing drugs during immunotherapy can be questioned.
Joint Effects of Febrile Acute Infection and an Interferon-γ Polymorphism on Breast Cancer Risk
TLDR
The findings indicate a possible link between febrile acute infection and a decreased risk of breast cancer, and this association was modified by IFN-γ rs2069705.
The role of innate immunity in spontaneous regression of cancer.
TLDR
An insight is provided into the benefits of fever and its role in prevention of cancer, the significance of common infections in cancer regression, the dual nature of the authors' immune system and the role of the often overlooked primary innate immunity in tumor immunology and spontaneous regression of cancer.
Fever Therapy With Intravenously Applied Mistletoe Extracts for Cancer Patients: A Retrospective Study
TLDR
IAMPs resulted in febrile reactions to >38.5°C in the majority of patients and can be considered as safe, and were mostly related to fever and were not severe.
Spontaneous remission in acute myeloid leukemia: A Case Report.
TLDR
A 35 years old male who was diagnosed with AML (M4) in Jan 2011, presented very ill with fever, bleeding tendency and oral candidacies, received supportive care only and chemotherapy was withheld, and died four weeks after relapse.
Spontaneous Regression of Ovarian Carcinoma After Septic Peritonitis; A Unique Case Report
TLDR
A unique case of spontaneous regression of ovarian carcinoma after septic peritonitis is presented, which shows strong activation of the immune system during sepsis overruled the immunosuppressive tumor microenvironment and allowed for a potent anti-tumor immune response.
Comparison of the Impact of Pro- and Antiinflammatory Immune Processes at the Two Immune-Deviated Sites, Eye and Solid Tumor and Possible Consequences for the Antitumoral Therapy with Fever Inducers
TLDR
The eye could be used as a model to develop hypotheses on how to abolish the immunological tolerance state of a solid tumor and make it susceptible to immunological destruction, and the knowledge gained in experimental studies abrogating immune privilege in the eye could provide insights into the inconsistent results of proinflammatory cancer therapy.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 277 REFERENCES
Febrile infections and malignant melanoma: results of a case-control study.
TLDR
The study confirms the hypothesis that an inverse relationship exists between febrile infections and malignant melanoma, but these results have to be interpreted cautiously due to the inherent limitations of the case-control design.
Reported herpes-virus-infection, fever and cancer incidence in a prospective study.
Spontaneous regression of cancer and the importance of finding its cause.
TLDR
There was no proven specific cause of the regression, but the following mechanisms had a possible relationship: immunologic action, elimination of carcinogens, trauma (altering the antigen-antibody relationship), hormones, irradiation, infection and/or fever, and drugs or chemicals.
Spontaneous regression of cancer and the importance of finding its cause.
  • W. Cole
  • Medicine
    National Cancer Institute monograph
  • 1976
TLDR
There was no proven specific cause of the regression, but the following mechanisms had a possible relationship: immunologic action, elimination of carcinogens, trauma, trauma (altering the antigen-antibody relationship), hormones, irradiation, infection and/or fever, and drugs or chemicals.
Chemotherapy of advanced epithelial cancer--a critical review.
  • U. Abel
  • Medicine
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
  • 1992
[Spontaneous remission of breast cancer. A literature review].
TLDR
On the basis of international literature, 32 cases of spontaneous remission of breast cancer are found and the phenomenon is therefore very rare and the natural course is very variable.
Risk of adult acute leukemia in relation to prior immune-related conditions.
  • G. Cooper, F. Kamel, D. Sandler, F. Davey, C. Bloomfield
  • Medicine, Biology
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • 1996
TLDR
The results offer little support for either a protective effect of enhanced immune surveillance or a harmful effect from antigenic stimulation in relation to risk for acute leukemia in adults, however, the associations between cancer risk and childhood infectious diseases are intriguing and may warrant additional research.
Beneficial effects of hepatitis in patients with acute myelogenous leukemia.
TLDR
Review of patients at this institution alive 2 years after the diagnosis of acute myelogenous leukemia showed that most had non-A, non-B post-transfusion hepatitis, which may have a beneficial effect on the leukemia or serve as an indicator of patients who have greater immunocompetence and thus a better prognosis.
Spontaneous regression in non‐hodgkin's lymphoma: Clinical and pathogenetic considerations
TLDR
Clinical experience as well as proposed mechanisms of spontaneous regression in non‐Hodgkin's lymphoma will be explored, which suggest indolent lymphomas which differ from aggressive lymphomas in their clinical and biological behavior may be more responsive to host immunoregulatory influences.
Childhood leukemia and infectious diseases in the first year of life: a register-based case-control study.
TLDR
The general infection risk profile of children with acute lymphocytic leukemia is compatible with these findings: there were more first-born children among the patients and more children from one-child families, and more rooms in patient's houses.
...
1
2
3
4
5
...