Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance


Toll-like receptor 4 (TLR4) has a key role in innate immunity by activating an inflammatory signaling pathway. Free fatty acids (FFAs) stimulate adipose tissue inflammation through the TLR4 pathway, resulting in insulin resistance. However, current evidence suggests that FFAs do not directly bind to TLR4, but an endogenous ligand for TLR4 remains to be… (More)
DOI: 10.1038/nm.2851


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