Fetomaternal immune cross-talk and its consequences for maternal and offspring's health

  title={Fetomaternal immune cross-talk and its consequences for maternal and offspring's health},
  author={Petra Clara Arck and K Hecher},
  journal={Nature Medicine},
An improved mechanistic understanding of the adaptational processes mounted during mammalian reproduction is emerging. Intricate pathways occurring at the fetomaternal interface, such as the formation of a functional synapse between invading fetal trophoblast cells, and the involvement of various maternal immune cell subsets and epigenetically modified decidual stromal cells have now been identified. These complex pathways synergistically create a tolerogenic niche in which the semiallogeneic… CONTINUE READING
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