Fetal thyroid function: diagnosis and management of fetal thyroid disorders.

  title={Fetal thyroid function: diagnosis and management of fetal thyroid disorders.},
  author={D. A. Fisher},
  journal={Clinical obstetrics and gynecology},
  volume={40 1},
  • D. A. Fisher
  • Published 1997 in Clinical obstetrics and gynecology
The fetal hypothalamic-pituitary-thyroid axis develops independently of the maternal axis, but it is dependent on the maternal-placental system for adequate supply of iodide substrate. This iodide is supplied by direct transfer of maternal plasma iodide and by placental deiodination of T4. In addition, although placental transport of iodothyronines is limited, significant maternal-fetal transfer of T4 occurs, accounting for approximately 30% of the average 10 ug/dL serum-T4 concentration in… CONTINUE READING
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