Fetal thymus graft prevents age-related hearing loss and up regulation of the IL-1 receptor type II gene in CD4+ T cells

  title={Fetal thymus graft prevents age-related hearing loss and up regulation of the IL-1 receptor type II gene in CD4+ T cells},
  author={Hiroshi Iwai and Muneo Inaba},
  journal={Journal of Neuroimmunology},
  • H. IwaiM. Inaba
  • Published 15 September 2012
  • Medicine, Biology
  • Journal of Neuroimmunology

Fetal thymus graft enables recovery from age-related hearing loss and expansion of CD4-Positive T cells expressing IL-1 receptor type 2 and regulatory T Cells

It is conceivable that the rejuvenation of systemic immune function by fetal thymus grafts contributes not only to the activation of cellular immunity but also to the decrease of IL-1R2+ CD4+ T cells or nTregs, which cells accelerate both age-related hearing loss (AHL) and neurodegeneration of the cochlear neurons.

Prevention of Hearing Loss by Alteration of the Systemic Immune System

Alterations in systemic immunity by fewer microbial antigen challenges in the living environment, elimination of immune suppressive lymphocytes, or immune rejuvenation with a reconstituted thymus may contribute not only to renew the cochlear function in SHL, but also to extend the healthy life of functional organs in a vigorous and youthful body.

A novel mechanism of tumor-induced thymic atrophy in mice bearing H22 hepatocellular carcinoma

This study revealed that CD8+ T cells could not effectively eliminate H22 cells independently when CD4- T cells were suppressed by tumors, while the body would only enhance the differentiation and maturation of T cells in thymuses and release them to solid tumor to reinforce antitumor immunocompetence, leading to a vicious cycle which finally led to thymic atrophy.

Mouse neutrophils express the decoy type 2 interleukin‐1 receptor (IL‐1R2) constitutively and in acute inflammatory conditions

The data show that in the mouse, neutrophils mainly express the decoy receptor IL‐1R2 under naïve and inflammatory conditions, and suggest that neutrophil may contribute to the resolution of acute inflammation.

Stem Cell Transplantation Upregulates Sirt1 and Antioxidant Expression, Ameliorating Fatty Liver in Type 2 Diabetic Mice

This is the first report of stem cell transplantation improving the antioxidant function in the liver, thymus, and bone marrow of db/db mice by increasing the levels of Sirt1 and HO-1.

Tuning inflammation and immunity by the negative regulators IL‐1R2 and IL‐1R8

The current understanding of the structure and function of IL‐1R2 and IL-1R8 is summarized, focusing on their role in different pathological conditions, ranging from infectious and sterile inflammation, to autoimmunity and cancer‐related inflammation.

New Allogeneic Hematopoietic Stem Cell Transplantation Method: Hematopoietic Stem Cell Transplantation Plus Thymus Transplantation for Intractable Diseases

  • N. Hosaka
  • Medicine, Biology
    Clinical & developmental immunology
  • 2013
A new HSCT method, HSCT + thymus transplantation (TT) from the same donor, which induces elevated T cell function with mild graft-versus-host disease (GVHD) in comparison to conventional HSCT alone and donor lymphocyte infusion (HSCT + DLI).



Sustained thymopoiesis and improvement in functional immunity induced by exogenous KGF administration in murine models of aging.

The result suggests that TEC damage is pathophysiologically important in thymic aging, and KGF therapy may be clinically useful in improving thymopoiesis and immune function in the elderly.

Impact of niche aging on thymic regeneration and immune reconstitution.

Maintenance of systemic immune functions prevents accelerated presbycusis

Keratinocyte growth factor (KGF) enhances postnatal T-cell development via enhancements in proliferation and function of thymic epithelial cells.

It is reported that KGF induces in vivo a transient expansion of both mature and immature thymic epithelial cells (TECs) and promotes the differentiation of the latter type of cells, providing new insights into the mechanism(s) of action of exogenous KGF on TEC function and thymopoiesis.

Age-related changes in lymphocyte development and function

This review aims to provide an overview of age-related changes in lymphocyte development and function and discusses current controversies in the field of aging research.

Aging and human CD4+ regulatory T cells

Rejuvenation of the aging T cell compartment.