Fetal stromal niches enhance human embryonic stem cell-derived hematopoietic differentiation and globin switch.

@article{Lee2011FetalSN,
  title={Fetal stromal niches enhance human embryonic stem cell-derived hematopoietic differentiation and globin switch.},
  author={King Yiu Lee and Benny Shu Pan Fong and Kam Sze Tsang and Tze Kin Lau and Pak Cheung Ng and Audrey Carmen Lam and Kathy Yuen Yee Chan and Chi Chiu Wang and Hsiang Fu Kung and Chi K Li and Karen Li},
  journal={Stem cells and development},
  year={2011},
  volume={20 1},
  pages={31-8}
}
Hematopoiesis during mammalian embryonic development has been perceived as a migratory phenomenon, from the yolk sac blood island to the aorta-gonad-mesonephros (AGM) region, fetal liver (FL), and subsequently, the fetal bone marrow. In this study, we investigated the effects of primary stromal cells from fetal hematopoietic niches and their conditioned media (CM), applied singly or in sequential orders, on induction of human embryonic stem cells, H1, H9, and H14 lines, to hematopoietic cells… CONTINUE READING
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