Fetal-specific CD8+ cytotoxic T cell responses develop during normal human pregnancy and exhibit broad functional capacity.

@article{Lissauer2012FetalspecificCC,
  title={Fetal-specific CD8+ cytotoxic T cell responses develop during normal human pregnancy and exhibit broad functional capacity.},
  author={David Lissauer and Karen P. Piper and Oliver C. Goodyear and Mark D Kilby and Paul Moss},
  journal={Journal of immunology},
  year={2012},
  volume={189 2},
  pages={
          1072-80
        }
}
Tolerance of the semiallogeneic fetus presents a significant challenge to the maternal immune system during human pregnancy. T cells with specificity for fetal epitopes have been detected in women with a history of previous pregnancy, but it has been thought that such fetal-specific cells were generally deleted during pregnancy as a mechanism to maintain maternal tolerance of the fetus. We used MHC-peptide dextramer multimers containing an immunodominant peptide derived from HY to identify… CONTINUE READING

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T cell behavior at the maternal-fetal interface.

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