Fetal serotonin reuptake inhibitor antidepressant exposure: maternal and fetal factors.

@article{Shea2012FetalSR,
  title={Fetal serotonin reuptake inhibitor antidepressant exposure: maternal and fetal factors.},
  author={Alison K. Shea and Tim F Oberlander and Dan W. Rurak},
  journal={Canadian journal of psychiatry. Revue canadienne de psychiatrie},
  year={2012},
  volume={57 9},
  pages={523-9}
}
Prenatal serotonin reuptake inhibitor exposure is common and neonatal outcomes vary greatly, often leading to confusion about whether to use or even continue antenatal use of these antidepressants. Importantly, some but not all infants are affected, which raises questions about how maternal drug metabolism contributes to fetal drug exposure. To address this key question, our paper reviews the role of key maternal, fetal, and placental pharmacokinetic, metabolic, and genetic factors that affect… CONTINUE READING