Fetal rat somatotropes in vitro: effects of insulin, cortisol, and growth hormone-releasing factor on their differentiation: a light and electron microscopic study.

@article{Hemming1984FetalRS,
  title={Fetal rat somatotropes in vitro: effects of insulin, cortisol, and growth hormone-releasing factor on their differentiation: a light and electron microscopic study.},
  author={Fiona J. Hemming and Martine Begeot and Maurice P. Dubois and Professeur Agr{\'e}g{\'e} P. M. Dubois},
  journal={Endocrinology},
  year={1984},
  volume={114 6},
  pages={2107-13}
}
Somatotropes first appear in the fetal rat pituitary just before term. These cells have never been detected in cultured fetal pituitaries. A modified culture medium has, however, enabled their differentiation in vitro. Hypophysial primordia were explanted on days 13-18 of gestation and cultured in different media until the equivalent of term. Immunoreactive somatotropes could be detected, by light and electron microscopy, in cultured primordia explanted on day 14 of gestation or later. The size… CONTINUE READING

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