Fetal programming of hypothalamic–pituitary–adrenal (HPA) axis function and behavior by synthetic glucocorticoids

@article{Kapoor2008FetalPO,
  title={Fetal programming of hypothalamic–pituitary–adrenal (HPA) axis function and behavior by synthetic glucocorticoids},
  author={Amita Kapoor and Sophie Petropoulos and Stephen G. Matthews},
  journal={Brain Research Reviews},
  year={2008},
  volume={57},
  pages={586-595}
}
Reduced fetal growth has been closely associated with an increased risk for the development of chronic disease in later life. Accumulating evidence indicates that fetal exposure to excess glucocorticoids represents a critical mechanism underlying this association. Approximately 7% of pregnant women are at risk of preterm delivery and these women are routinely treated with synthetic glucocorticoids (sGC) between 24 and 34 of weeks gestation to improve neonatal outcome. Animal studies have… CONTINUE READING

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