Fetal programming and adult health

@article{Godfrey2001FetalPA,
  title={Fetal programming and adult health},
  author={Keith M. Godfrey and David J. P. Barker},
  journal={Public Health Nutrition},
  year={2001},
  volume={4},
  pages={611 - 624}
}
Abstract Low birthweight is now known to be associated with increased rates of coronary heart disease and the related disorders stroke, hypertension and non-insulin dependent diabetes. These associations have been extensively replicated in studies in different countries and are not the result of confounding variables. They extend across the normal range of birthweight and depend on lower birthweights in relation to the duration of gestation rather than the effects of premature birth. The… Expand
The role of the placenta in fetal programming-a review.
The fetal origins hypothesis proposes that adult cardiovascular and metabolic disease originate through developmental plasticity and fetal adaptations arising from failure of the materno-placentalExpand
Perinatal Programming and Blood Pressure
TLDR
This chapter discusses both epidemiologic data and experimental models that elucidate those factors involved in perinatal programming and developmental origins of adult disease that have profound effects on the fetus and neonate. Expand
Early Human Growth
TLDR
Most pregnancy complications originate in the periconceptional period and first trimester growth restriction has been related to an increased risk of adverse birth outcomes, including being born SGA. Expand
Maternal inflammation, growth retardation, and preterm birth: insights into adult cardiovascular disease.
TLDR
The "fetal origin of adult disease Hypothesis" originally described by Barker et al. identified the relationship between impaired in utero growth and adult cardiovascular disease risk and death and is essential for the treatment of upcoming generations. Expand
Diet during pregnancy, neonatal outcomes and later health.
TLDR
Against a history of inconsistent results, several recent studies suggest that in Western settings the balance of macronutrients in a woman's diet can influence newborn size, and improved diet before pregnancy deserves greater attention. Expand
Fetal programming of coronary heart disease
  • D. Barker
  • Medicine
  • Trends in Endocrinology & Metabolism
  • 2002
TLDR
Coronary heart disease appears to be a developmental disorder that originates through two widespread biological phenomena, developmental plasticity and compensatory growth. Expand
Coronary Heart Disease: A Disorder of Growth
  • D. Barker
  • Medicine
  • Hormone Research in Paediatrics
  • 2003
A new ‘developmental’ model for the origins of coronary heart disease and the related disorders of type 2 diabetes, hypertension and stroke is emerging. The finding that people who develop theseExpand
Mechanisms by which poor early growth programs type-2 diabetes, obesity and the metabolic syndrome
TLDR
This work has utilised various species to test the early life programming hypothesis and to identify key molecular mechanisms which can be validated as realistic targets for intervention. Expand
Programming and reproductive functioning
TLDR
It is concluded that the concept of programming can be applied to reproductive development and related health outcomes, and that the complex potential for interactions between parameters controlling fetal development and postnatal exposures invokes a need to adopt a perspective across the life course of an individual. Expand
Maternal obesity, metabolism, and pregnancy outcomes.
  • J. King
  • Medicine
  • Annual review of nutrition
  • 2006
TLDR
Current dietary guidelines regarding the amount and type of carbohydrates and fat for nonpregnant women seem appropriate for pregnant women as well, as studies of women with impaired glucose tolerance show that replacing refined carbohydrates and saturated fat with complex, low-glycemic carbohydrates and polyunsaturated fatty acids improves metabolic homeostasis and pregnancy outcomes. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 79 REFERENCES
Dysfunction of placental glucocorticoid barrier: link between fetal environment and adult hypertension?
TLDR
The lifetime risk of common disorders may be partly determined by the intrauterine environment, supported by findings that in rats decreased activity of the enzyme that acts as a placental barrier to maternal glucocorticoids is associated with low birthweight. Expand
Maternal nutrition and fetal growth.
TLDR
The reviewer concludes that the undesirable consequence of strict dietary restrictions during pregnancy must now be abundantly clear and should receive wide publicity. Expand
Birthweight, body-mass index in middle age, and incident coronary heart disease
TLDR
There is an important interaction between birthweight and BMI such that the increased risk of coronary heart disease associated with low birthweight is restricted to people who have high BMI in adulthood. Expand
Compensatory placental growth after restricted maternal nutrition in early pregnancy.
TLDR
There was an increase in placental weight, but not in birthweight, in infants whose mothers' nutrition was compromised around conception or in the first trimester of pregnancy, which suggests that pregnancy undernutrition can stimulate compensatory placental growth. Expand
Elevated plasma cortisol concentrations: a link between low birth weight and the insulin resistance syndrome?
TLDR
This study provides the first evidence that intrauterine programming of the HPAA may be a mechanism underlying the association between low birth weight and the insulin resistance syndrome in adult life and suggests that plasma concentrations of cortisol within the normal range could have an important effect on blood pressure and glucose tolerance. Expand
Maternal and fetal influences on blood pressure.
TLDR
Patterns of placental weight, birth weight, head circumference, and length that are associated with high blood pressure in adults are also associated with higherBlood pressure in 4 year old children. Expand
Growth in utero, adult blood pressure, and arterial compliance.
TLDR
Impairment of fetal growth is associated with raised blood pressure in adult life and decreased compliance in the conduit arteries of the trunk and legs. Expand
Compensatory Placental Growth After Restricted Maternal Nutrition in Early Pregnancy
TLDR
There was an increase in placental weight, but not in birthweight, in infants whose mothers’ nutrition was compromised around conception or in the first trimester of pregnancy, which suggests that pregnancy undernutrition can stimulate compensatory placental growth. Expand
Compensatory placental growth after restricted maternal nutrition in early pregnancy.
TLDR
There was an increase in placental weight, but not in birthweight, in infants whose mothers' nutrition was compromised around conception or in the first trimester of pregnancy, which suggests that pregnancy undernutrition can stimulate compensatory placental growth. Expand
Glucose tolerance in adults after prenatal exposure to famine
TLDR
Prenatal exposure to famine, especially during late gestation, is linked to decreased glucose tolerance in adults, and this effect of famine on glucose tolerance is especially important in people who become obese as adults. Expand
...
1
2
3
4
5
...