Fetal pathology in rats following uterine-vessel clamping on day 14 of gestation.

@article{Leist1974FetalPI,
  title={Fetal pathology in rats following uterine-vessel clamping on day 14 of gestation.},
  author={K. Leist and J. Grauwiler},
  journal={Teratology},
  year={1974},
  volume={10 1},
  pages={
          55-67
        }
}
The main uterine vessels of pregnant rats were clamped on day 14 for 30, 60, or 90 min. The fetal death rate was increased by 60 or 90 min clamping, proportional to duration. Some surviving fetuses showed skeletal retardation, bilateral limb anomalies, and cleft palate when examined on day 21. As early as 3 h after declamping, edema was seen in the mesenchymal tissue of the limbplates, together with a marked dilatation of the fetal vessels. Later this tissue became necrotic. The necrotic… Expand
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