Fetal origins of developmental plasticity: Animal models of induced life history variation

  title={Fetal origins of developmental plasticity: Animal models of induced life history variation},
  author={Teresa H Horton},
  journal={American Journal of Human Biology},
  • T. Horton
  • Published 2005
  • Biology
  • American Journal of Human Biology
The interaction of the genetic program with the environment shapes the development of an individual. Accumulating data from animal models indicate that prenatal and early‐postnatal events (collectively called “early‐life events”) can initiate long‐term changes in the expression of the genetic program which persist, or may only become apparent, much later in the individual's life. Researchers working with humans or animal models of human diseases often view the effects of early‐life events… 

The thrifty phenotype as an adaptive maternal effect

  • J. Wells
  • Biology
    Biological reviews of the Cambridge Philosophical Society
  • 2007
This article argues that the thrifty phenotype is the consequence of three different adaptive processes ‐ niche construction, maternal effects, and developmental plasticity ‐ all of which in humans are influenced by the authors' large brains.

Developmental plasticity and epigenetic mechanisms underpinning metabolic and cardiovascular diseases.

The evidence that susceptibility to metabolic and cardiovascular disease in humans is linked to changes in epigenetic marks induced by early-life environmental cues is reviewed, and the clinical, public health and therapeutic implications that arise are discussed.

Developmental Origins of Adult Function and Health: Evolutionary Hypotheses

This review critically evaluates proposals for an adaptive function of metabolic responses to nutritional stress in humans and concludes with strategies for testing these models for predictive plasticity.

Evolutionary genetic bases of longevity and senescence.

  • D. Govindaraju
  • Biology
    Advances in experimental medicine and biology
  • 2015
It is suggested that synergistic and cascading effects of cis-ruptive mechanisms in the genome, and epigenetic disruptive processes in relation to environmental factors may lead to sequential slippage in the G-E-P space.

Fetal programming: Adaptive life‐history tactics or making the best of a bad start?

  • James Holland Jones
  • Biology
    American journal of human biology : the official journal of the Human Biology Council
  • 2005
It is suggested that an adequate model of human life‐history evolution must account for the highly structured nature of the human life cycle, with its late age at first reproduction, large degree of iteroparity, highly overlapping generations, and extensive, post‐weaning parental investment.

Impact of Prenatal Stress on Neuroendocrine Programming

Considering the higher potential for neonatal plasticity within the brain in human beings as compared to other species, long-term consequences of prenatal stress might not be as inexorable as suggested in animal-based studies published to date.

Development of individual differences in stress responsiveness: an overview of factors mediating the outcome of early life experiences

It is shown that nonshared experiences acquired through within-litter variation in maternal care in rats predict the stress phenotype of the offspring.

Maternal photoperiod programs hypothalamic thyroid status via the fetal pituitary gland

This study defines the pathway by which maternal melatonin engages with the fetal brain and shows how this prenatal signal leads to a long-term effect on brain thyroid hormone signaling, establishing a new paradigm for investigating epigenetic programming of brain function in utero.

Embryo-fetal origin of diseases - new approach on epigenetic reprogramming

Dynamic state of genome in periconceptional and perinatal period made it extremely susceptible for adverse effects on epigenetic modification producing life-long consequences and increased chance for adult disease, so new approach to prevention, diagnosis and treatment in this vulnerable period is needed.



Developmental Origins of Disease Paradigm: A Mechanistic and Evolutionary Perspective

The “developmental origins of disease” paradigm is a reflection of the persistence of such mechanisms in humans who now live in very different environments from those within which they evolved and have major implications for addressing the increasing burden of metabolic and cardiovascular disease.

Developmental Plasticity: Developmental Conversion versus Phenotypic Modulation

The developmental mechanisms by which the environment may alter the phenotype during development are reviewed and the relationship between developmental plasticity and evolutionary plasticity are examined.

The Evolution of Life History Traits: A Critique of the Theory and a Review of the Data

Two models which give alternative explanations for the adaptation of life history traits to stable and fluctuating environments are reviewed and tried to understand what life history data could mean in general, given the present state of knowledge.

Genetics and Evolution of Phenotypic Plasticity

Phenotypic plasticity is the change in the expressed phenotype of a genotype as a function of the environment, and is likely due both to differences in allelic expression across environments and to changes in interactions among loci.

Evolutionary Analyses of Morphological and Physiological Plasticity in Thermally Variable Environments

A general methodological framework for studying the evolution of plastic responses is described, suggesting that an understanding of selection and evolution of thermal acclimation will be enhanced by experimental examinations of mechanistic links between traits and environments, of the physiological bases and functional consequences of acclimations, of patterns of environmental variability and predictability, ofThe fitness consequences of Acclimation in nature, and of potential genetic constraints are suggested.

Natural selection and the evolution of genome imprinting.

A closer look at parental origin-dependent differences in chromatin structure suggests that these differences might be subject to some common forces and that these forces may explain many of the "nontranscriptional" parental origin effects observed in mammals.

The developmental origins of the metabolic syndrome

Sexual Differentiation of the Brain: Genes, Estrogen, and Neurotrophic Factors

It was concluded that the axogenic effect of E2 depends on interaction between neurons and glia from a target region and that neurons from fetal male donors appear to mature earlier than neurons from females, a differentiated response that takes place prior to divergent exposure to gonadal secretions.

Life-History Tactics: A Review of the Ideas

  • S. Stearns
  • Biology
    The Quarterly Review of Biology
  • 1976
This review organizes ideas on the evolution of life histories into more comprehensive theory that makes more readily falsifiable predictions, and examination of different definitions of fitness.

The Relations between Genetics and Epigenetics

The polysemy of the word epigenetics is unpacked by adopting a historical point of view and by focusing on the models that were proposed at the beginning of the 1960s to explain variations in gene activity during cell differentiation and development.